Page 126 - Zbornik_Konf_2019

https://doi.org/10.15414/2019.9788055220703

4 International Scientific Conference Abstracts Book
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RESEARCH ABOUT THE EFFICIENCY OF USING SALIX ALBA L. AND SALVIA OFFICINALIS L.
IN MEDICINE AND PHARMACY

Vladislav Postoy, Diana Mykhailyk, Liliia Vyshnevska
National Pharmaceutical University, Kharkiv, Ukraine; E-mail.: myhailyk99@ukr.net

Today in the world there are about 12 thousand plants that have healing properties and
are used in both traditional and folk medicine. Most often medicinal plants are combined with
synthetic substances and other methods of treatment. Herbal medicine is a valuable
biogenetic complex that includes active substances: flavonoids, tannins, essential oils, trace
elements, vitamins and more. This complex has been formed in a living cell, and therefore has
a greater resemblance to the human body than an isolated, chemically pure active substance,
therefore it is easier to assimilate and gives fewer side effects.
The object of our study was Salix alba L. and Salvia officinalis L. In Ukraine, there are
about 30 species of willow biology are distributed, of which 27 are wild and 3 are cultivated.
The bark of willow is used from ancient times. Willow extract is used to reduce pain and
inflammation. The main active ingredient is salicin (0.5 %) – a compound that is similar in its
quality to aspirin. Once in the body, salicin is cleaved in the liver to salicylic acid, which leads
to a violation of the synthesis of inflammatory mediators by blocking the enzyme
cyclooxygenase. As a result, these active substances do not cause inflammatory reactions,
including pain. When administered inside the willow promotes improvement in diarrhea and
gastritis, dysentery, colitis, arthritis, rheumatism, neuralgia, fever, bronchitis, neurosis. When
used externally helps with sweating, sore throat, has a bactericidal effect on the oral cavity
during rinsing. Preparations of white willow bark are presented in the form of crushed
powder (extract), tablets, capsules, and tea.
Sage is a plant that has a wide medical popularity. The leaves of the sage contain
essential oil (0.5–2.5 %), tannins (4 %), triterpene acids (ursolov and oleanol), diterpenes,
resinous substances (5–6 %) and bitter, flavonoids, coumarin, esculin and others substances
The plant has an expectorant effect, so sage is part of the herbal collection for the treatment of
bronchitis, diuretic properties that allow the treatment of kidney disease. Anti-inflammatory
properties of sage help to treat angina, inflammation of the gums and inflammation on the
skin. Antimicrobial and antifungal properties are successfully used for the treatment of skin
diseases. Sage has a beneficial effect on the work of the brain, it is recommended for
prolonged mental workloads and for improving memory. Angiogenesis (the process of
formation of blood vessels) plays a key role in the growth and maturation of tumors. It is
important for growth, spread of metastases or invasion into organs and tissues. Studies in the
field of oncology have shown that a certain therapeutic dose of sage contains ursolic acid,
which can suppress the formation of blood vessels in the tumor in the body of the animal and
humans. In phytotherapy and folk medicine, the sage is included in the form of internal
medicine (infusions, decoctions, tinctures, teas, pills, lozenges, syrups, and mixtures), as well
as external (concentrates for lotions, baths, ointments, gels, creams, shampoos).
To sum up, we have developed a gel with white willow bark extract and sage leaves for
the treatment of acute and chronic inflammation of the joints. The composition of the gel is
methyl salicylate as a base used hydroxyethylcellulose.

Keywords: Salix alba, Salvia officinalis, salicin, essential oil, inflammation.

|126 4 International Scientific Conference Agrobiodiversity Nutrition, Health and Quality of Human and Bees Life
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September 11–13, 2019