Page 101 - Zbornik_Konf_2019

https://doi.org/10.15414/2019.9788055220703

4 International Scientific Conference Abstracts Book
th
RESEARCH OF EXTRACTION CONDITIONS OF PHYTOCOMPOSITION FOR NON–
HORMONAL TREATMENT OF THE MENOPAUSE
Ilona Konovalenko, Natalia Polovko

National University of Pharmacy, Kharkiv, Ukraine; E-mail.: ilonakonovalenko1601@gmail.com
The aim of the research was to study the influence of pharmaceutical factors on the
preparation of aqueous extracts from medicinal plants for non-hormonal therapy of
menopausal syndrome.
An imbalance of hormones and a sharp decrease in the amount of estrogen negatively
affect the well-being and general condition, causing a lot of unpleasant sensations and
exacerbation of some chronic diseases. In this regard, the search for alternative treatments for
menopausal syndrome, including herbal preparations, is relevant. Preparations that include
medicinal plant materials have a wide range of pharmacological activity due to the
combination of various groups of biologically active substances in their composition, a slight
risk of allergic reactions, a mild effect, a small spectrum of side effects and lower toxicity to
the organs of the excretory system in comparison with preparations of microbial, hormonal
and chemical synthesis.
In the Ukrainian pharmaceutical market there are very few biologically active
substances used for non-hormonal therapy of menopausal syndrome of Ukrainian production,
which makes the manufacture of biologically active substances of Ukrainian origin relevant
and promising. The advantages of domestic production of medicines in the form of fees
include: the availability of a sufficient raw material base, the patient has the opportunity to
get the drug at an affordable price.
One of the important stages in the complex of studies when creating new drugs is the
rationale for rational technology. Since the medicinal product in the form of a collection is a
solid dosage form, and its use in medical practice is advisable in the form of infusions and
decoctions, the justification of the optimal manufacturing conditions of both the collection
itself and water extracts from it should be based on a complex of pharmacotechnological
studies.
Other factors influence the completeness of biologically active substances in the
preparation of aqueous extracts, among which the extraction mode plays an important role.
Therefore, when developing a rational technology for obtaining water extracts, it is necessary
to justify the duration of infusion in a water bath and subsequent infusion at room
temperature after removal from the bath.
In order to study the influence of various pharmaceutical factors, three collection
fractions studied, which were identical in composition but different in particle size
fragmentation, and selected by sieving through sieves No. 1, 2, 3. Medicinal raw materials
were milled with the grass cutting. The particle size of the first fraction was 1-2 mm, the
second fraction was 2-4 mm, and the third was 4-6 mm.
Raw materials were placed in a heated tunic, filled with purified room temperature
water at a ratio of 1:10, taking into account the coefficient of water absorption, insisted on a
boiling water bath, left for further cooling at room temperature. Then the resulting infusion
was filtered, bringing the total volume of the aqueous extract from the biologically active
substances with purified water to the required volume.
We studied the effect of various pharmaceutical factors on the yield of extractives. We
determined the dependence of the yield of extractives from the drug collection at various
degrees of dispersion of raw materials.

Keywords: phytocomposition, extraction, menopause.

4 International Scientific Conference Agrobiodiversity Nutrition, Health and Quality of Human and Bees Life |101
th
September 11–13, 2019