Page 71 - Zbornik_Konf_2019

https://doi.org/10.15414/2019.9788055220703

4 International Scientific Conference Abstracts Book
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ESTIMATION OF ANTHROPOGENIC LOADING OF THE HUMAN BODY BY CHEMICAL
ELEMENTS ACCORDING TO THE DATA OF ECOLOGICAL AND HYGIENIC MONITORING IN
UKRAINE
Iryna Andrusyshyna, Inna Golub, Olena Lampeka, Andrey Andrusyshyn

GI “Kundiiev Institute of Occupational Health of HAMS of Ukraine”, Kyiv, Ukraine;
E-mail: andrusyshyna.in@gmail.com

In the modern urban environment, the effect of chemical elements (as aluminium, silver,
manganese, chromium and others) represents a pressing issue in the context of both
anthropogenic burden and occupational health impact, so the examination of their action can
provide support to the justification of regional reference values which eventually will ensure
the implementation of efficient and effective hygienic measures. Thus, the purpose of this
research was to reveal the profile of the specific impact of metals as low-dose factors on the
endocrine system and to build the basis for justification of their optimal levels in biological
media, to improve the methodological approaches to pathogenesis, diagnostics and assessment
of risk.
Samples of soil (40 samples), air (48 samples), drinking water (182 samples), food (246
samples) and biosubstrates (hair, whole blood, serum, saliva and urine- all 100 samples) on the
content of Al, Ag, As, Cd, Cr, Mn, Pb, Са, Mg, Fe, Se, Ni, Cu, and Zn) were prepared according to
the validated and approved method on the instrument of optical emission-spectrometry with
inductively coupled plasma (OES-ICP) on the device Optima 2100 DV from Perkin-Elmer (USA).
Complex environmental and hygienic studies revealed the consistent toxicant pattern
with different trends in various environmental samples. For instance, a gradual increase in
metal level is observed in soil (43 % for Al and 2.45 – fold for Zn), in air (9-fold for Al, 5-fold for
Ni, 4-fold for Mg, 6-fold for Mn, 30 % for Zn), in drinking water (tap water: 1.6 TLV (Са), 1.2 TLV
(Mg); artesian water: 1.45 TLV (Mn), 1.2 TLV (Fe), 1.1 TLV (Pb) and in food products
(vegetables and breads: 1.02–2.90 TLV (Al and Cr); meat products: 3.0 TLV (Cr), milk products
and breads: 1.4-1.6 TLV (Pb)). At the same time, a certain deficit of essential elements (Se, Ca,
Mg, Cu, Zn) was detected in drinking water and food products. It was demonstrated that Al, Cd,
Cr, Mn, and Zn levels in various environmental compartments make these metals priority
exposition markers for future researches.
The obtained results allowed to justify metal concentrations in biological media for Ag,
Al, Mn, and Cr exposure which met the acceptable level of the health risk according to criteria of
endocrine functional changes. It was established that the content of microelements in biological
media examined in a number of cases corresponded to their minimum physiological levels (Pb,
Zn, Cd, Mg, Se), optimal levels (Mn, Fe, Cu, Ni, Ca) and maximum physiological levels (As and Al).
Optimal blood levels are 0.20 mg/l (Al), 0.02 mg/l (Ag), 0.02 mg/l (Cr) and 0.038 mg/l (Mn);
and when they are exceeded, the surrounding environment is considered to be an increased
risk environment in the context of exposition to these metals.
The conducted research allowed to expand the methodological approaches to the
complex hygienic and environmental assessment of the metal effect on the development of
endocrine pathology; optimal levels of these metals in human biological media were justified
and evaluation of the environment-associated risk of endocrine disorders in man was
performed.
Keywords: metals as low-dose factors, reference values, endocrine system, occupational risk.

4 International Scientific Conference Agrobiodiversity Nutrition, Health and Quality of Human and Bees Life |71
th
September 11–13, 2019